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KMID : 0379520020180030267
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한국독성학회지
2002 Volume.18 No. 3 p.267 ~ p.273
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The Safety Evaluation of a Potent Antioxidant, Fructose 1,6-diphosphate(FDP), for the Skin Application
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Kim Bae-Hwan
Lee Byoung-Seok
Jung Kyoung-Mi
Ahn Soo-Mi
An Su-Sun
Shim Young-Chul
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Abstract
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Fructose 1,6-diphosphate(FDP), a glycolytic metabolite, is reported to ameliorate inflammation and inhibit the nitric oxide production in murine macrophages stimulated with endotoxin. It is also reported that FDP has cytoprotective effects against hypoxia or ischemia/reperfusion injury in brain and heart, and may play a protective role in ultraviolet B (UVB, 280~320 nm)-injured keratinocyte by attenuating prostaglandin (PG)-E_2production and cyclooxygenase (COX)-2 expression, which are possibly through blocking the intracellular reactive oxygen species (ROS) accumulation. Therefore FDP is considered to act as a potent antioxidant especially in the skin. We conducted the several safety tests (single-dose toxicity, primary skin irritation test, eye irritation test, skin sensitization test, phototoxicity test, photosenitization test and human patch test) to see if FDP is safe in case used for the skin application. Our data obtained hitherto suggest that FDP is very safe if applied to the skin.
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KEYWORD
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Fructose 1, 6-diphosphate(FDP), Antioxidant, Anti-inflammatory, Safety evaluation, Skin application
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